Renal Diseases of in Cats

Polycystic kidney disease was first described in adult male and female long-haired, Persian-type cats in the late 1960’s. In 1996, the disorder was shown to be inherited as an autosomal dominant trait in a family of Persian cats. Both male and female cats were affected. In affected × unaffected crosses, 42% of offspring were affected and 58% were unaffected. In affected × affected crosses, 73% of progeny were affected and 27% were unaffected. These results were consistent with autosomal dominant transmission. Recently, the prevalence of autosomal dominant polycystic kidney disease (ADPKD) in Persian cats has been reported to be approximately 28% in the United Kingdom, based on results of a genetic assay using a single nucleotide polymorphism in exon 29 of the polycystin gene.